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KMID : 0545120160260030567
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 3 p.567 ~ p.571
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A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift
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Kim Hyeun-Bum
Wang Yuan Kai
Sun Xing Min
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Abstract
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We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.
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KEYWORD
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Microbiota, Clostridium difficile infection, Antibiotics, Immunosuppressive drug, Gut
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